Vesicular Stomatitis Virus-Vectored Multi-Antigen Tuberculosis Vaccine Limits Bacterial Proliferation in Mice following a Single Intranasal Dose
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Vesicular Stomatitis Virus-Vectored Multi-Antigen Tuberculosis Vaccine Limits Bacterial Proliferation in Mice following a Single Intranasal Dose
Tuberculosis (TB) remains a serious health problem worldwide, and an urgent need exists to improve or replace the available vaccine, Mycobacterium bovis bacillus Calmette-Guérin (BCG). Most vaccination protocols adapt two or three doses to induce long-term lasting immunity. Our previous study showed that the naked DNA encoding the triple-antigen fusion TFP846 (Rv3615c-Mtb10.4-Rv2660c) induced r...
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Corresponding author: Leo Lefrançois Department of Immunology University of Connecticut Health Center M/C 1319 263 Farmington Avenue Farmington, CT 06030-1319 Phone (860) 679-3242 Fax (860) 679-1868 e-mail [email protected] AC CE PT ED Copyright © 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Virol. doi:10.1128/JVI.02167-06 JVI Ac...
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Andes virus (ANDV) is highly pathogenic in humans and is the primary etiologic agent of hantavirus cardiopulmonary syndrome (HCPS) in South America. Case-fatality rates are as high as 50% and there are no approved vaccines or specific therapies for infection. Our laboratory has recently developed a replication-competent recombinant vesicular stomatitis virus (VSV)-based vaccine that expressed t...
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We have generated replication-competent (VSV-C/E1/E2) and nonpropagating (VSVDeltaG-C/E1/E2) vesicular stomatitis virus (VSV) contiguously expressing the structural proteins of hepatitis C virus (HCV; core [C] and glycoproteins E1 and E2) and report on their immunogenicity in murine models. VSV-C/E1/E2 and VSVDeltaG-C/E1/E2 expressed high levels of HCV C, E1, and E2, which were authentically po...
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In the course of the manifold and persistent searches for an aetiological agent in rheumatoid arthritis (RA) it has been reported that cultured synovial cells from patients suffering from RA fail to be infected by a strain of rubella virus or by Newcastle disease virus (Smith and Hamerman, 1969; Grayzel and Beck, 1970); this was taken as evidence for a pre-existent occult virus infection of the...
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ژورنال
عنوان ژورنال: Frontiers in Cellular and Infection Microbiology
سال: 2017
ISSN: 2235-2988
DOI: 10.3389/fcimb.2017.00034